Alternative Medicine in Neuropathic Pain Opioids in the Spinal Cord and Central Sensitization Spinothalamic Tract Neurons, Role of Nitric Oxide Long-Term Potentiation and Long-Term Depression in the Spinal Cord
نویسنده
چکیده
This is a long-lasting increase in synaptic efficacy resulting from repetitive activation of the synapse. This process was first described in hippocampus, whereby high-frequency stimulation of afferent pathways leads to a potentiated post-synaptic response that can last for hours to days. It is a form of activity-dependent plasticity. LTPmay increase the efficiencyof pain transmission for weeks to months or longer. Alternative Medicine in Neuropathic Pain Opioids in the Spinal Cord and Central Sensitization Spinothalamic Tract Neurons, Role of Nitric Oxide
منابع مشابه
TRPV1 in GABAergic Interneurons Mediates Neuropathic Mechanical Allodynia and Disinhibition of the Nociceptive Circuitry in the Spinal Cord
Neuropathic pain and allodynia may arise from sensitization of central circuits. We report a mechanism of disinhibition-based central sensitization resulting from long-term depression (LTD) of GABAergic interneurons as a consequence of TRPV1 activation in the spinal cord. Intrathecal administration of TRPV1 agonists led to mechanical allodynia that was not dependent on peripheral TRPV1 neurons....
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تاریخ انتشار 2007